Development of plasmonic quorum sensors for understanding bacteria-eukaryotic cell relations

ERC Advanced Grant Project

PLASMAQUO is an ERC Advanced Grant Project granted to Prof. Luis Liz-Marzán by the European Research Council under the European's Union Seventh Framework Programme (FP7/2007-2013) /ERC grant agreement n° 267867. The 5 year research project started the 1st of March of 2011 and will run until the 28th of February 2016. More details.

Project Members


PLASMAQUO aims at the development of novel nanostructured materials based on crystalline assemblies of anisotropic plasmonic (gold/silver) nanoparticles, to be used for the surface enhanced Raman scattering (SERS) detection of quorum sensing (QS) signaling molecules, and to the demonstration of applications of such materials to monitor population kinetics in bacterial colonies and the determination of the interaction mechanisms between mixed colonies and their manipulation through external parameters.

This will involve a first stage related to the careful design of the most appropriate nanoparticle morphology and composition, as well as an understanding of their specific assembly processes (both on substrates and in solution), so that the collective plasmonic response will be optimized towards the enhancement of the Raman signal of the probe molecular codes. Coating of the nanoparticle supercrystals with a mesoporous layer will be required to protect them against contact with bacteria and cells, while permitting contact with the QS signalling molecules.

Ultimately, when the sensing system has been optimized and its performance demonstrated for monitoring of QS signals and colony growth, two final and important goals will be pursued. First, the interaction between mixed colonies (bacteria-bacteria and bacteria-eukaryotic cell) will be monitored in order to get information about synergic or antagonist (toxicity) QS mechanisms during the growth and proliferation of different bacteria and interspecies. This goal will permit the design of in vitro experiments where a bacterial strain may be manipulated by means of external introduction of the appropriate QS signalling molecules. Finally, the major challenge will be the practical demonstration of the ability of these new materials in this particular configuration for understanding and manipulating the growth and communication of different types of prokaryotic and peukaryotic cells.

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15. G. Bodelón, V. Montes-García, V. López-Puente, E.H. Hill, C. Hamon, M.N. Sanz-Ortiz, S. Rodal-Cedeira, C. Costas, S. Celiksoy, I. P&éacute;rez-Juste, L. Scarabelli, A. La Porta, J. P&éacute;rez-Juste, I. Pastoriza-Santos, L.M. Liz-Marzán , Detection and Imaging of Quorum Sensing in Pseudomonas Aeruginosa Biofilm Communities by Surface-Enhanced Resonance Raman Scattering
Nature Materials, in press
14. M. Grzelczak, A. Sánchez-Iglesias, H. Heidari, S. Bals, I. Pastoriza-Santos, J. P&éacute;rez-Juste, L.M. Liz-Marzán , Silver Ions Direct Twin Plane Formation During the Overgrowth of Single Crystal Gold Nanoparticles
ACS Omega 2016, 1, 177-181
13. E.H. Hill, N. Claes, S. Bals, L.M. Liz-Marzán, Layered Silicate Clays as Templates for Anisotropic Gold Nanoparticle Growth
Chem. Mater. 2016, 28, 5131-5139
12. M. Oroval, M. Coronado-Puchau, J. Langer, M.N. Sanz-Ortiz, A. Ribes, C. Coll, M.D. Marcos, F. Sancenón, L.M. Liz-Marzán, R. Martínez-Máñez, Surface Enhanced Raman Scattering and Gated Materials for Sensing Applications. The Ultrasensitive Detection of Mycoplasma and Cocaine
Chem. Eur. J., in press
11. K.W. Smith, H. Zhao, H. Zhang, A. Sánchez-Iglesias, M. Grzelczak, Y. Wang, W.-S. Chang, P. Nordlander, L.M. Liz-Marzán, S. Link, Chiral and Achiral Nanodumbbell Dimers: The Effect of Geometry on Plasmonic Properties
ACS Nano 2016, 10, 6180-6188
10. D. Zanaga, T. Altantzis, L. Polavarapu, L.M. Liz-Marzán, B. Freitag, S. Bals, Quantitative XEDS tomography of complex hetero-nanostructures
Part. Part. Syst. Charact. 2016, 33, 396-403
9. G. González-Rubio, A. Guerrero-Martínez, L.M. Liz-Marzán, Reshaping, Fragmentation and Assembly of Gold Nanoparticles Assisted by Pulse Lasers
Acc. Chem. Res. 2016, 49, 678-686
8. J. Reguera, D. Jimenez de Aberasturi, N. Winckelmans, J. Langer, S. Bals, L.M. Liz-Marzán, Synthesis of Janus Plasmonic-Magnetic, Star-Sphere Nanoparticles, and Their Application in SERS Detection
Faraday Discuss., in press
7. C. Hamon, M.N. Sanz-Ortiz, E. Modin, E. Hill, L. Scarabelli, A. Chuvilin, L.M. Liz-Marzán, Hierarchical Organization and Molecular Diffusion in Gold Nanorod/Silica Supercrystal Nanocomposites
Nanoscale 2016, 8, 7914-7922
6. A. Espinosa, A.K.A. Silva, A. Sánchez-Iglesias, M. Grzelczak, C. P&éacute;choux, K. Desboeufs, L.M. Liz-Marzán, C. Wilhelm, Cancer cell internalisation of gold nanostars impacts their photothermal efficiency in vitro and in vivo: towards a plasmonic thermal fingerprint in tumoral environment
Adv. Healthcare Mater. 2016, 5, 1040-1048
5. A.M. Percebom, J.J. Giner-Casares, N. Claes, S. Bals, W. Loh, L.M. Liz-Marzán, Janus Gold Nanoparticles Obtained via Spontaneous Binary Polymer Shell Segregation
Chem. Commun. 2016, 52, 4278-4281
4. A. Li Volsi, D. Jimenez de Aberasturi, M. Henriksen-Lacey, G. Giammona, M. Licciardi, L.M. Liz-Marzán, Inulin Coated Plasmonic Gold Nanoparticles as a Tumor-Selective Tool for Cancer Therapy
J. Mater. Chem. B 2016, 4, 1150-1155
3. J.J. Giner-Casares, M. Henriksen-Lacey, M. Coronado-Puchau, L.M. Liz-Marzán, Inorganic Nanoparticles for Biomedicine: Where Materials Scientists Meet Medical Research
Materials Today 2016, 19, 19-28
2. J.J. Giner-Casares, M. Henriksen-Lacey, I. García, L.M. Liz-Marzán, Plasmonic Surfaces for Cell Growth and Near-Infrared Light Triggered Retrieval
Angew. Chem. Int. Ed. 2016, 55, 974-978
1. D. Zanaga, F. Bleichrodt, T. Altantzis, N. Winckelmans, W.J. Palenstijn, A. Sánchez-Iglesias, J. Sijbers, B. de Nijs, M.A. van Huis, L.M. Liz-Marzán, A. van Blaaderen, K.J. Batenburg, S. Bals, G. Van Tendeloo, Quantitative 3D analysis of huge nanoparticle assemblies
Nanoscale 2016, 8, 292-299

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25. V. López-Puente, P.C. Angelom&éacute;, G.J.A.A. Soler-Illia, L.M. Liz-Marzán, Selective SERS Sensing Modulated by Functionalized Mesoporous Films
ACS. Appl. Mater. Interfaces 2015, 7, 25633-25640 Read article here.
24. Y. Wang, K. Sentosun, A. Li, M. Coronado-Puchau, A. Sánchez-Iglesias, S. Li, X. Su, S. Bals, L.M. Liz-Marzán, Engineering Structural Diversity in Gold Nanocrystals by Ligand-Mediated Interface Control
Chem. Mater. 2015, 27, 8032-8040. Read article here.
23. L. Scarabelli, A. Sánchez-Iglesias, J. P&éacute;rez-Juste, L.M. Liz-Marzán, A “tips ’n tricks” Practical Guide to the Synthesis of Gold Nanorods
J. Phys. Chem. Lett. 2015, 6, 4270-4279. Read article here.
22. M.N. Sanz-Ortiz, K. Sentosun, S. Bals, L.M. Liz-Marzán, Templated Growth of Surface Enhanced Raman Scattering-Active Branched Au Nanoparticles within Radial Mesoporous Silica Shells
ACS Nano 2015, 9, 10489–10497. Read article here .
21. B. Goris, J. De Beenhouwer, A. De Backer, D. Zanaga, K.J. Batenburg, A. Sánchez-Iglesias, L.M. Liz-Marzán, S. Van Aert, S. Bals, J. Sijbers, G. Van Tendeloo, Measuring lattice strain in three dimensions through electron microscopy
Nano Lett. 2015, 15, 6997–7002. Read article here.
20. C. Hamon, S.M. Novikov, L. Scarabelli, D.M. Solís, T. Altantzis, S. Bals, J.M. Taboada, F. Obelleiro, L.M. Liz-Marzán, Collective Plasmonic Properties in Few-Layer Gold Nanorod Supercrystals
ACS Photonics 2015, 2, 1482–1488. Read article here .
19. B.B. Rajeeva, D.S. Hernandez, M. Wang, E. Perillo, L. Lin, L. Scarabelli, B. Pingali, L.M. Liz-Marzán, A.K. Dunn, J.B. Shear, Y. Zheng, Regioselective Localization and Tracking of Biomolecules on Single Gold Nanoparticles
Adv. Sci. 2015, 1500232
18. A.B. Serrano-Montes, D. Jimenez de Aberasturi, J. Langer, J.J. Giner-Casares, L. Scarabelli, A. Herrero, L.M. Liz-Marzán, A General Method for Solvent Exchange of Plasmonic Nanoparticles and Self-Assembly into SERS-Active Monolayers
Langmuir 2015, 31, 9205–9213
15. J.J. Giner-Casares, M. Henriksen-Lacey, M. Coronado-Puchau, L.M. Liz-Marzán, Inorganic Nanoparticles for Biomedicine: Where Materials Scientists Meet Medical Research
Materials Today, in press
14. M. Mayer, L. Scarabelli, K. March, T. Altantzis, M. Tebbe, M. Kociak, S. Bals, F.J. García de Abajo, A. Fery, L.M. Liz-Marzán, Controlled Living Nanowire Growth: Precise Control over the Morphology and Optical Properties of AgAuAg Bimetallic Nanowires
Nano Lett. 2015, 15, 5427–5437
13. C. Costas, V. Lopez-Puente, G. Bodelon, C. González-Bello, J. Perez-Juste, I. Pastoriza-Santos, L.M. Liz-Marzan, Using Surface Enhanced Raman Scattering to Analyze the Interactions of Protein Receptors with Bacterial Quorum Sensing Modulators
ACS Nano 2015, 9, 5567–5576
12. Y. Wang, A.B. Serrano, K. Sentosun, S. Bals, L.M. Liz-Marzán, Stabilization and Encapsulation of Gold Nanostars Mediated by Dithiols
Small 2015, 11, 4314–4320
11. J. Langer, S. Novikov, L.M. Liz-Marzán, Sensing using plasmonic nanostructures and nanoparticles
Nanotechnology 2015, 26, 322001
10. A. La Porta, A. Sánchez-Iglesias, T. Altantzis, S. Bals, M. Grzelczak, L.M. Liz-Marzán, Multifunctional Self-Assembled Composite Colloids and their Application to SERS Detection
Nanoscale 2015, 7, 10377–10381. Read article here.
9. C. Hamon, L.M. Liz-Marzán, Hierarchical assembly of plasmonic nanoparticles
Chem. Eur. J., 2015, 21, 9956–9963
8. D. Rodríguez-Fernández, J. Langer, M. Henriksen-Lacey, L.M. Liz-Marzán, Hybrid Au-SiO2 Core-Satellite Colloids as Switchable SERS Tags
Chem. Mater. 2015, 27, 2540–2545. Read article here.
7. G. Bodelón, V. Montes-García, C. Fernández-López, I. Pastoriza-Santos, J. P&éacute;rez-Juste, L.M. Liz-Marzán, Au@pNIPAM SERRS Tags for Multiplex Immunophenotyping Cellular Receptors and Imaging Tumor Cells
Small 2015, 11, 4149–4157
6. I. García, A. Sánchez-Iglesias, M. Henriksen-Lacey, M. Grzelczak, S. Penad&éacute;s, L.M. Liz-Marzán, Glycans as Biofunctional Ligands for Gold Nanorods: Stability and Targeting in Protein-Rich Media
J. Am. Chem. Soc. 2015, 137, 3686–3692
5. D. Jimenez de Aberasturi, A.B. Serrano-Montes, L.M. Liz-Marzán, Modern Applications of Plasmonic Nanoparticles: From Energy to Health
Adv. Opt. Mater. 2015, 3, 602–617
4. A. Losquin, L.F. Zagonel, V. Myroshnychenko, B. Rodríguez-Gonzalez, M. Tenc&éacute;, L. Scarabelli, J. Förstner, L.M. Liz-Marzán, F.J. García de Abajo, O. St&éacute;phan, M. Kociak, Unveiling nanometer scale extinction and scattering phenomena through combined electron energy loss spectroscopy and cathodoluminescence measurements
Nano Lett. 2015, 15, 1129–1237. Read article here.
3. E. Farrokhtakin, D. Rodríguez-Fernández, V. Mattoli, D.M. Solís, J.M. Taboada, F. Obelleiro, M. Grzelczak, L.M. Liz-Marzán, Radial Growth of Plasmon Coupled Gold Nanowires on Colloidal Templates
J. Colloid Interface Sci. 2015, 449, 87–91
2. B.H.Juarez, L.M. Liz-Marzán, Microgels and Nanoparticles: Where Micro and Nano Go Hand in Hand
Z. Phys. Chem. 2015, 229, 263–282
1. A. Shiohara, S.M. Novikov, D.M. Solís, J.M. Taboada, F. Obelleiro, L.M. Liz-Marzán, Plasmon Modes and Hot Spots in Gold Nanostar-Satellite Clusters
J. Phys. Chem. C 2015, 119, 10836-10843. Read article here.

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30. C. Hamon, S. Novikov, L. Scarabelli, L. Basabe-Desmonts, L.M. Liz-Marzán, Hierarchical Self-Assembly of Gold Nanoparticles into Patterned Plasmonic Nanostructures
ACS Nano 2014, 8, 10694–10703. Read article here.
29. H. Xie, Y. Lin, M. Mazo, C. Chiappini, A. Sánchez-Iglesias, L.M. Liz-Marzán, M.M. Stevens, Identification of Intracellular Gold Nanoparticles Using Surface-enhanced Raman Scattering
Nanoscale 2014, 6, 12403-12407.
28. A. Shiohara, Y. Wang, L.M. Liz-Marzán, Recent Approaches Toward Creation of Hot Spots for SERS Detection
J. Photochem. Photobiol. C 2014, 21, 2–25.
27. D.M. Solís, J.M. Taboada, F. Obelleiro, L.M. Liz-Marzán, F.J. García de Abajo, Towards Ultimate Nanoplasmonics Modeling
ACS Nano 2014, 8, 7559–7570. Read article here.
26. L. Polavarapu, J. P&éacute;rez-Juste, Q.-H. Xu, L.M. Liz-Marzán, Optical Sensing of Biological, Chemical and Ionic Species Through Aggregation of Plasmonic Nanoparticles
J. Mater. Chem. C 2014 , 2 , 7460-7476. Read article here
25. B. Goris, G. Guzzinati, C. Fernández-López, J. P&éacute;rez-Juste, L.M. Liz-Marzán, A. Trügler, U. Hohenester, J. Verbeeck, S. Bals, G. van Tendeloo, Plasmon Mapping in Au@Ag Nanocube Assemblies
J. Phys. Chem. C 2014, 118, 15356–15362
24. M. Grzelczak, L.M. Liz-Marzán, Exploiting Hydrophobic Interactions at the Nanoscale
J. Phys. Chem. Lett. 2014, 5, 2455–2463. You can access the article here.
23. S. Bals, B. Goris, L.M. Liz-Marzán, G. Van Tendeloo, Three-Dimensional Characterization of Metal Nanoparticles and their Assemblies by Electron Tomography
Angew. Chem. Int. Ed. 2014, 53, 10600–10610
22. A. Shiohara, J. Langer, L. Polavarapu, L.M. Liz-Marzán, Solution Processed Polydimethylsiloxane/ Gold Nanostar Flexible Substrates for Plasmonic Sensing
Nanoscale 2014, 6, 9817–9823. Read article here
21. J.J. Giner-Casares, L.M. Liz-Marzán, Plasmonic Nanoparticles in 2D for Biological Applications: Towards Active Multipurpose Platforms
Nano Today 2014, 9, 365–377
20. A. La Porta, M. Grzelczak, L.M. Liz-Marzán, Gold Nanowire Forests for SERS Detection
ChemistryOpen 2014, 3, 146–151
19. V. Montes-García, J. P&éacute;rez-Juste, I. Pastoriza-Santos, L.M. Liz-Marzán, Metal Nanoparticles and Supramolecular Macrocycles: A Tale of Synergy
Chem. Eur. J. 2014, 20, 10874–10883
18. M. Grzelczak, A. Sánchez-Iglesias, L.M. Liz-Marzán, A General Approach toward Polymer-Coated Plasmonic Nanostructures
CrystEngComm 2014, 16, 9425–9429. Read article here.
17. Y. Wang, L. Polavarapu, L.M. Liz-Marzán, Reduced Graphene Oxide-Supported Gold Nanostars for SERS Sensing and Drug Delivery
ACS Appl. Mater. Interf., 2014, 6, 21798−21805. You can access the article here.
16. L. Polavarapu, A. La Porta, S.M. Novikov, M. Coronado-Puchau, L.M. Liz-Marzán, Pen-on-paper Approach Toward the Design of Universal Surface Enhanced Raman Scattering Substrates
Small 2014, 10, 3065–3071
15. G. Bodelón, S. Mourdikoudis, L. Yate, I. Pastoriza-Santos, J. P&éacute;rez-Juste, L.M. Liz-Marzán, Nickel Nanoparticle-Doped Paper as a Bioactive Scaffold for Targeted and Robust Immobilization of Functional Proteins
ACS Nano 2014, 8, 6221–6231. You can access the article here.
14. L. Scarabelli, M. Coronado-Puchau, J.J. Giner-Casares, J. Langer, L.M. Liz-Marzán, Monodisperse Gold Nanotriangles: Size Control, Large-Scale Self-Assembly and Performance in Surface Enhanced Raman Scattering
ACS Nano 2014, 8, 5833–5842. Read article here.
13. L. Saa, M. Coronado-Puchau, V. Pavlov, L.M. Liz-Marzán, Enzymatic Etching of Gold Nanorods by Horseradish Peroxidase and Application to Blood Glucose Detection
Nanoscale, 2014, 6, 7405-7409.You can access the article here.
12. B. Goris, L. Polavarapu, S. Bals, G. Van Tendeloo, L.M. Liz-Marzán, Monitoring Galvanic Replacement Through Three-Dimensional Morphological and Chemical Mapping
Nano Lett. 2014, 14, 3220–3226. Read article here.
11. P.C. Angelome, L.M. Liz-Marzán, Synthesis and Applications of Mesoporous Nanocomposites Containing Metal Nanoparticles
J. Sol-Gel Sci. Technol. 2014, 70, 180–190
10. R. Cao-Milán, L. M. Liz-Marzán, Gold nanoparticle conjugates: recent advances toward clinical applications
Exp. Op. Drug. Del. 2014, 11, 741–752
9. J. E. Galván-Moya, T. Altantzis, K. Nelissen, F.M. Peeters, M. Grzelczak, L.M. Liz-Marzán, S. Bals, G. Van Tendeloo, Self-organisation of highly symmetric nanoassemblies: a matter of competition
ACS Nano 2014, 8, 3869–3875. Read article here.
8. M. Grzelczak, L.M. Liz-Marzán, The relevance of light in the formation of colloidal metal nanoparticles
Chem. Soc. Rev. 2014, 43, 2089–2097. Read article here.
7. L. M. Maestro, P. Haro-González, A. Sánchez-Iglesias, L.M. Liz-Marzán, J.G. Sol&éacute;, D. Jaque, Quantum dot thermometry evaluation of geometry dependent heating efficiency in gold nanoparticles
Langmuir 2014, 30, 1650–1658. Read article here.
6. N. Almora-Barrios, G. Novell-Leruth, P. Whiting, L.M. Liz-Marzán, N. López, Theoretical description of the role of halides, silver, and surfactants on the structure of gold nanorods
Nano Lett. 2014, 14, 871–875. Read article here.
5. D. Rodríguez-Fernández, T. Altantzis, H. Heidari, S. Bals, L.M. Liz-Marzán, A Protecting Group Approach toward Au-Silica Janus Nanostars
Chem. Commun. 2014, 50, 79–81. Read article here.
4. S. Abalde-Cela, C. Abell, R.A. Alvarez-Puebla, L.M. Liz-Marzán, Real-Time Dual-Channel Multiplex SERS Ultradetection
J. Phys. Chem. Lett. 2014, 5, 73–79. View the presentation of the article at ACS LiveSlides TM.
3. S.E. Lohse, N.D. Burrows, L. Scarabelli, L.M. Liz-Marzán, C.J. Murphy, Anisotropic Noble Metal Nanocrystal Growth: The Role of Halides
Chem. Mater., 2014, 26, 34-43
2. S.M. Novikov, A. Sánchez-Iglesias, M.K. Schmidt, A. Chuvilin, J. Aizpurua, M. Grzelczak, L.M. Liz-Marzán, Gold Spiky Nanodumbbells. Anisotropy in Gold Nanostars
Part. Part. Syst. Charact., 2014, 26, 77-80
1. L.M. Liz-Marzán, The Basque Country Special Issue
Part. Part. Syst. Charact., 2014, 26, 9-10



16. A.K. Samal, L. Polavarapu, S. Rodal-Cedeira, L.M. Liz-Marzán, J. P&éacute;rez-Juste, I. Pastoriza-Santos, Size Tunable Au@Ag Core-Shell Nanoparticles: Synthesis and SERS Properties
Langmuir 2013, 29, 15076–15082. Read article here.
15. L. Scarabelli, M. Grzelczak, L.M. Liz-Marzán, Tuning Gold Nanorod Synthesis Through Pre-reduction with Salicylic Acid
Chem. Mater. 2013, 25, 4232–4238
14. M. Coronado-Puchau, L. Saa, M. Grzelczak, V. Pavlov, L.M. Liz-Marzán, Enzymatic Modulation of Gold Nanorod Growth and Application to Nerve Gas Detection
Nano Today 2013, 8, 461–468. Read article here.
13. V. López-Puente, S. Abalde-Cela, P.C. Angelom&éacute;, R.A. Alvarez-Puebla, L.M. Liz-Marzán, Plasmonic Mesoporous Composites as Molecular Sieves for SERS Detection
J. Phys. Chem. Lett. 2013, 4, 2715–2720. View the presentation of the article at ACS LiveSlides TM. Read article here.
12. M. Grzelczak, A. Sánchez-Iglesias, L.M. Liz-Marzán, Solvent-induced division of plasmonic clusters
Soft Matter 2013, 9, 9094–9098. Read article here.
11. S. Gómez-Graña, B. Goris, T. Altantzis, C. Fernández-López, E. Carbó-Argibay, A. Guerrero-Martínez, N. Almora-Barrios, N. López, I. Pastoriza-Santos, J. P&éacute;rez-Juste, S. Bals, G. Van Tendeloo, L.M. Liz-Marzán, Au@Ag Nanoparticles: Halides stabilize {100} facets
J. Phys. Chem. Lett. 2013, 4, 2209–2216. View the presentation of the article at ACS LiveSlides TM. Read article here.
10. S. Gómez-Graña, J. P&éacute;rez-Juste, R. A. Alvarez-Puebla, A. Guerrero-Martínez and L. M. Liz-Marzán, Self-assembly of Au@Ag Nanorods Mediated by Gemini Surfactants for Highly Efficient SERS-Active Supercrystals
Adv. Opt. Mater. 2013, 4, 477–481
9. L. Polavarapu and L. M. Liz-Marzán, Growth and Galvanic Replacement of Silver Nanocubes in Organic Medium
Nansoscale, 2013, 5, 4355 - 4361. Read article here.
8. M. Grzelczak, L. M. Liz-Marzán Colloidal Nanoplasmonics. From Building Blocks to Sensing Devices
Langmuir, 2013, 29, 4652–4633. Read article here.
7. A. Lombardi , M. P. Grzelczak , A. Crut, P. Maioli , I. Pastoriza-Santos , L. M. Liz-Marzán , N. Del Fatti , and F. Vall&éacute;e, Optical Response of Individual Au-Ag@SiO2 Hetero-Dimers
ACS Nano., 2013, 7, 2522–2531. Read article here.
6. S. Mourdikoudis, L.M. Liz-Marzán, Oleylamine in nanoparticle synthesis
Chem. Mater., 2013, 25, 1465–1476. Link to cover page. Most Read article from Chemistry of Materials between January and March 2013. Read article here.
5. A.F. Alvarez-Paneque, B. Rodríguez-González, I. Pastoriza-Santos, L.M. Liz-Marzán, Shape-templated growth of Au@Cu nanoparticles
J. Phys. Chem. C, 2013, 117, 2474-2479.Read article here.


L. Polavarapu, L.M. Liz-Marzán, Towards Low-cost Flexible Substrates for Nanoplasmonic Sensing
Phys. Chem. Chem. Phys., 2013, 15, 5288-5300. Read article here.
3. Y. Zhao, L. Xu, L.M. Liz-Marzán, H. Kuang, W. Ma, A. Asenjo-García, J. Garcia de Abajo, N. A. Kotov, L. Wang, C. Xu, Alternating Plasmonic Nanoparticle Heterochains Made by Polymerase Chain Reaction and Their Optical Properties
J. Phys. Chem. Lett., 2013, 4, 641–647 . Read article here.

T. Altantzis, B. Goris, A. Sánchez-Iglesias, M. Grzelczak, L.M. Liz-Marzán, S. Bals, Quantitative structure determination of large 3-dimensional nanoparticle assemblies
Part. Part. Syst. Charact., 2013, 30, 84-88 (frontispiece)

1. D. Rodríguez-Fernández, L.M. Liz-Marzán, Metallic Janus and patchy particles
Particle Part. Syst. Charact. 2013, 30, 46–60


17. A. Sánchez-Iglesias, M. Grzelczak, T. Altantzis, B. Goris, J. Perez-Juste, S. Bals, G. Van Tendeloo, S.H. Donaldson Jr., B.F. Chmelka, J.N. Israelachvili, L.M. Liz-Marzán, Hydrophobic Interactions Modulate Self-assembly of Nanoparticles
ACS Nano, 2012, 6, 11059-11065. Read article here.
16. M. Chanana, L.M. Liz-Marzán, Coating matters: the influence of coating materials on the optical properties of gold nanoparticles
Nanophotonics 2012,1, 199-220
15. N. Pazos-P&éacute;rez, A. Wittemann, C.S. Wagner, J.M. Romo-Herrera, L.M. Liz-Marzán, F.J. Garcia de abajo, A. Fery, R.A. Alvarez-Puebla, Organized plasmonic clusters with high coordination number and extraordinary SERS enhancement
Angew. Chem. Int. Ed. 2012, 51, 12688–12693
14. R.A. Alvarez-Puebla, L.M. Liz-Marzán, SERS Detection of Small Inorganic Molecules and Ions
Angew. Chem. Int. Ed. 2012, 51, 11214–11223
13. B. Goris, S. Bals, W. Van den Broek, E. Carbó-Argibay, S. Gómez-Graña, L.M. Liz-Marzán, G. Van Tendeloo, Atomic scale determination of surface facets in nanocrystals
Nat. Mater. 2012, 11, 930-935 Read article here.
Highlighted in Nature Materials News and Views
12. B. Pelaz, S. Jaber, D. Jimenez de Aberasturi, V. Wulf, T. Aida, J.M. de la Fuente, J. Feldmann, H.E. Gaub, L. Josephson, C.R. Kagan, N.A. Kotov, L.M. Liz-Marzán, H. Mattoussi, P. Mulvaney, C.B. Murray, A.L. Rogach, P.S. Weiss, I. Willner, W.J. Parak, The State of Nanoparticle-Based Nanoscience and Biotechnology: Progress, Promises, and Challenges
ACS Nano, 2012, 6, 8468–8483. Read article here.
11. R. Ahijado-Guzmán, P. Gómez-Puertas, G. Rivas, R.A. Alvarez-Puebla, L.M. Liz-Marzán, SERS-based detection of the interactions between the essential cell division FtsZ protein and bacterial membrane elements
ACS Nano, 2012, 6, 7514-7520. Read article here.
10. V. Myroshnychenko, J. Nelayah, G. Adamo, N. Geuquet, J. Rodríguez-Fernández, I. Pastoriza-Santos, K. MacDonald, L. Henrard, L.M. Liz-Marzán, N.I. Zheludev, M. Kociak, F.J. García de Abajo, Plasmon Spectroscopy and Imaging of Individual Gold Nanodecahedra: A Combined Optical Microscopy, Cathodoluminescence, and Electron Energy-Loss Spectroscopy Study
Nano Lett., 2012, 12, 4172-4180. Read article here.
9. L. Rodríguez-Lorenzo, R. de la Rica, R. Alvarez-Puebla, L.M. Liz-Marzán, M.M. Stevens, Plasmonic nanosensors with inverse sensitivity by means of enzyme-guided crystal growth
Nature Mater., 2012, 11, 604-607.Cover image. Read article here.

Highlighted in Nature Materials (link) and Nature Reviews Urology (link), Nature Asia, Nano Today, Physics World (link), Reuters (link), Science Daily (link)…)
8. P. Aldeanueva-Potel, E. Carbó-Argibay, S. Barbosa, N. Pazos-Pérez, I. Pastoriza-Santos, R.A. Alvarez-Puebla, L.M. Liz-Marzán, Spiked Gold Beads as Substrates for Single-Particle SERS
ChemPhysChem, 2012, 13, 2561-2565. Cover image.

7. N. Talebi, W. Sigle, R. Vogelgesang, C.T. Koch, C. Fernández-López, L.M. Liz-Marzán, B. Ögüta, M. Rohma, P.A. van Aken, Breaking the Mode Degeneracy of Surface-Plasmon Resonances in a Triangular System
Langmuir, 2012, 28, 8867-8873. Read article here.
6. A. Jiménez-Solano, C. López-López, O. Sánchez-Sobrado, J.M. Luque, M.E.Calvo, C. Fernández-López, A. Sánchez-Iglesias, L.M. Liz-Marzán, H. Míguez, Integration of Gold Nanoparticles in Optical Resonators
Langmuir, 2012, 28, 9161-9167. Read article here.
5. A. Guerrero-Martínez, M. Grzelczak, L.M. Liz-Marzán, Molecular Thinking for Nanoplasmonic Design
ACS Nano, 2012, 6, 3655-3662. Read article here.
4. D. Rodríguez-Fernández, I. Pastoriza-Santos, J. Pérez-Juste, L.M. Liz-Marzán, Colloidal Synthesis of Gold Semishells
Chemistry Open, 2012, 1, 90-95
3. P.C. Angelomé, H.H. Mezerji, B. Goris, I. Pastoriza-Santos, J. Pérez-Juste, S. Bals, L.M. Liz-Marzán, Seedless Synthesis of Single Crystalline Au Nanoparticles with Unusual Shapes and Tunable LSPR in the Near-IR
Chem. Mater., 2012, 24, 1393-1399. Read article here.
2. P.C. Angelomé, I. Pastoriza-Santos, J. Pérez-Juste, B. Rodríguez-González, A. Zelcer, G. Soler-Illia, L.M. Liz-Marzán, Growth and Branching of Gold nanoparticles Through Mesoporous Silica Thin Films
Nanoscale, 2012, 4, 931-939. Read article here.
1. R.A. Alvarez-Puebla, L.M. Liz-Marzán, Traps and Cages for Universal SERS detection
Chem. Soc. Rev., 2012, 41, 43-51. Read article here.

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Project Members

Project head: Prof. Luis Liz-Marzán


  • Principal Investigator
    • Prof. Luis M. Liz-Marzán
  • Postdoctoral Research Associates
    • Dr. Malou Henriksen
    • Dr. Eric Hill
  • Research Assistant
    • Ana Sánchez-Iglesias
  • Management
    • Dr. Anna Llanes-Pallàs


  • Associate Professors
    • Dr. Jorge Pérez-Juste
    • Dr. Isabel Pastoriza-Santos
  • Postdoctoral Research Associates
    • Dr. Gustavo Bodelón

Former Members


  • Postdoctoral Research Associates
    • Dr. Cyrille Hamon
    • Dr. Lakshminarayana Polavarapu
    • Dr. Juan Jos&éacute; Giner Casares
    • Dr. Amane Shiohara
    • Dr. Sergey Novikov
  • Ph. D. Students
    • Marc Coronado
    • Leonardo Scarabelli
    • Andrea La Porta


  • Postdoctoral Research Associates
    • Dr. Celina Costas
    • Dr. Paula C. Angelom&éacute;
  • Ph. D. Students
    • Dionysia Tsoutsi
    • Sergio Gómez-Graña
    • Verónica Montes Garcia
    • Laura álvarez Franc&éacute;s
  • Technicians
    • Cristina Fernández-López
  • Management
    • Dr. Gema Antequera-García
    • José Antonio Cuadrado-Martín
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